Infection Diseases / Infections

What does "infection puzzle" mean?

The "infection puzzle" refers to the significant variability in clinical outcomes observed among individuals with infections (3, 4). There is enormous individual clinical variation in the course of any infection (3).

What likely determines the outcome of an infection?

Although data on infection fatality are lacking, it is generally believed that the outcome of an infection is determined primarily by qualitative (pathogenicity) and quantitative (inoculum) microbial factors (1).

What is likely the main cause of death from infections?

Geneticists propose that the root cause of death from infections lies in the host's determinants, which can be inherited or acquired, overt or covert (3, 4). The prevalence of death from infection in unvaccinated humans is generally…