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Methotrexate (MTX) + Tofacitinib is approved by the FDA and EMA for the treatment of Rheumatoid Arthritis (RA) in adult patients who do not respond adequately to methotrexate alone or are intolerant to other DMARDs. Tofacitinib can be administered as monotherapy or in combination with methotrexate, and several clinical studies have …