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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Aging / Senescence & Branched-chain amino acids (BCAAs)

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Restriction of BCAAs, particularly leucine, isoleucine, and valine, results in increased lifespan in Fruit flies and mice
Lu et al. 2020 Nat. Aging 1: 60-72
Richardson et al. 2021 Nat. Aging 1: 73-86

It appears that this effect is associated with an inhibition of mTOR signaling.
Lee et al. 2021e Science 374: 953

References (Sources)

Antiaging diets: Separating fact from fiction
Lee et al. 2021e Science 374: 953
Review
Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and lifespan in mice
Richardson et al. 2021b Nat. Aging 1: 73-86
Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids
Lu et al. 2020h Nat. Aging 1: 60-72

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Aging / Senescence & Branched-chain amino acids (BCAAs)

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