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Unlike Conventional Natural Killer (cNK) Cells, Tissue-Resident ILC1 are primarily found within specific tissue niches and do not circulate. They also express NK1.1 and CD335 (NKp46) and are regulated by TBET. A key distinguishing feature of tissue-resident ILC1s is their dependency on the transcription factor Hypermethylated in Cancer 1 (HIC1) for their development and maintenance within tissues such as the liver
see also:
Group 1 ILCs (ILC1)
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