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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Biological effects / Functions & Lipid droplets (LDs)

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More recently, we demonstrated that Lipid droplets (LDs) have a complex antibacterial activity, which is upregulated in mice treated with the lipopolysaccharide (LPS), a potent activator of innate immunity, or subjected to a polymicrobial sepsis.
Bosch et al. 2020a Science 370(6514): eaay8085

In LPS-activated cells, LDs accrue proteins

with anti-pathogenic activity,

involved in immune signaling,

mediating inflammation, and

regulating immunometabolism.

Safi et al. 2023 Immunol Rev 314:…

References (Sources)

Defensive‐lipid droplets: Cellular organelles designed for antimicrobial immunity
Safi et al. 2023 Immunol Rev 314:
Review
Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defense
Bosch et al. 2020a Science 370(6514): eaay8085

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Biological effects / Functions & Lipid droplets (LDs)

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