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Increased expression of MUCIN-1 (MUC1) is linked to a high metastatic potential and poor prognosis in cancer patients (). MUC1 is a protein expressed on nearly all human epithelial cells, particularly in adenocarcinomas ().
Carcinoma-associated mucins, such as MUC1, are believed to be the initial points of contact with other cells, including lymphocytes (; ; ). This interaction is crucial in the immune response and cancer progression.
[Cytotoxic T …