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Poly (ADP-ribose) polymerases (PARPs) help fix DNA damage
Poly (ADP-ribose) polymerase 1 (PARP1) and Poly (ADP-ribose) polymerase 2 (PARP2) repair DNA single-strand breaks. They attach PAR chains to DNA breaks. This recruits other repair proteins. Without PARP, single-strand breaks become double-strand breaks. This process triggers complex repair pathways that require functional BRCA genes. These include homologous recombination repai…