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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

AuthorsReferences (Sources)

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Colorectal Cancer (CRC) & Interleukin-17 Family / Interleukin-17 (IL-17)

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Although the results indicate a potential therapeutic benefit of targeting Interleukin-17 Family / Interleukin-17 (IL-17), the heterogeneity of CD4+ Th17 cells makes it difficult to conclude their exact function in human Colorectal Cancer (CRC). Further research is needed before initiating clinical trials.
Kempski et al. 2017

Moreover, increased frequencies of IL-17A-producing cells were found in human Colorectal Cancer (CRC), and high [Interleukin-17 Family / Interleukin-17 (IL-17)](brain://gxTb-ttgjlqhmWcXTkFzYg/Interleukin17Family…

References (Sources)

Enrichment of Inflammatory IL-17 and TNF-α Secreting CD4(+) T Cells within Colorectal Tumors despite the Presence of Elevated CD39(+) T Regulatory Cells and Increased Expression of the Immune Checkpoint Molecule, PD-1
Dunne et al. 2016 Front Oncol 6: 50
Integrative analyses of colorectal cancer show immunoscore is a stronger predictor of patient survival than microsatellite instability
Mlecnik et al. 2016 Immunity (44(3): 698-711
Interleukin-17 and type 17 helper T cells in cancer management and research
Llosa et al. 2014
Review
Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis
Wang et al. 2014a Immunity 41(6): 1052-63
Redundant Innate and Adaptive Sources of IL17 Production Drive Colon Tumorigenesis.
Housseau et al. 2016 Cancer Res. 76: 2115-2124
TH17 cell and epithelial cell crosstalk during inﬂammatory bowel disease and carcinogenesis
Kempski et al. 2017
Review

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7/1/2026

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