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To increase efficacy, bacterial delivery platforms have been developed that improve safety and prolong treatment. Bacteria are a unique class of therapy that selectively colonizes most solid tumors. As delivery vehicles, bacteria have been genetically modified to express a range of therapies that match multiple cancer indications.
A modular “build-a-bug” method that focuses on five design characteristics: bacterial strain (chassis), therapeutic compound, delivery method, immune-modulating features, and genetic control circuits is described
The genomes of gut microbes are fertile grounds for discovery of components to improve delivery and modulate host immune responses.
Raman et al. 2023 Cell Ho…