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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Biological effects / Functions & Farnesoid X receptor (FXR / NR1H4)

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Activation of Farnesoid X receptor (FXR / NR1H4) by bile acid binding leads to heterodimerization with Retinoid X receptor alfa (RXR-alfa) and subsequent transcriptional changes
Way et al. 2022 Cells 11: 1374

Intestinal Farnesoid X receptor (FXR / NR1H4) induces Fibroblast Growth Factor 15/19 (FGF15/19) in the ileum
Fuchs & Trauner 2022 Nat Rev Gastroenterol Hepatol 19: 432-450

It also induces a [bile salt export pump (BSEP)](brain://ZN-C…

Interactions between bile salts, gut microbiota, and hepatic innate immunity
Schubert et al. 2017 Immunological Reviews 279: 23-35
Review
Key Signaling in Alcohol-Associated Liver Disease: The Role of Bile Acids
Way et al. 2022 Cells 11: 1374
Review
Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology
Fuchs & Trauner 2022 Nat Rev Gastroenterol Hepatol 19: 432-450
Review

7/1/2026