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Allogeneic hematopoietic cell transplantation (HCT) is the only potentially curative therapy for myelodysplastic syndromes (MDS), although it is infrequently offered to older patients.
In contrast to 5-azacytidine (5-aza), Allogeneic hematopoietic stem cell transplantation (allo HSCT) represents a curative treatment strategy for patients with Myelodysplastic-myeloproliferative neoplasms (MDS) but therapy-related mortality (TRM) limits its broader use in elderly patients with MDS.
In older patients with MDS, reduced-intensity conditioning HSCT resu…