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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

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Inulin-type fructans (ITF) / Inulin + Resistant starch (RS) & Alzheimer's disease (AD)

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Preclinical data

Inulin improves intestinal microbial metabolism in APOE4 mice and exhibits sex-specific anti-inflammatory effects.
Chang et al. 2023 Sci Rep. 13(1): 15116

One study examined the effects of inulin on mice carrying the APOE4 allele, a significant genetic risk factor for Alzheimer's. Inulin can restore metabolic functions and balance the gut microbiome in these mice, potentially reducing the risk of Alzheimer’s Disease.
Chang et al. 2020a Alzheimer's & Dementia 16(Suppl. 10): e041175

References (Sources)

Apolipoprotein E Genotype-Dependent Nutrigenetic Effects to Prebiotic Inulin for Reducing Risk for Alzheimer’s Disease in a Mouse Model
Chang et al. 2020a Alzheimer's & Dementia 16(Suppl. 10): e041175
Prebiotic inulin enhances gut microbial metabolism and anti-inflammation in apolipoprotein E4 mice with sex-specific implications
Chang et al. 2023 Sci Rep. 13(1): 15116

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