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The nonclassical antigen-presenting molecule MHC class I-related protein 1 (MR1) plays a crucial role in the immune system by presenting microbial metabolites to mucosal-associated invariant T (MAIT) cells, thus facilitating their activation and subsequent immune response.
Unlike classical MHC molecules, which present peptide antigens, MR1 is specialized in presenting small organic molecules derived from the metabolic processes of microbes.
The structure of MR1 allows it to bind ligands originating from vit…