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A systematic review and meta-analysis (CRD42023471128) examined the efficacy of Immune Checkpoint Inhibitors (ICIs) versus Cetuximab + Cisplatin + Fluorouracil (5-FU) (EXTREME scheme) in R/M Head & Neck squamous cell carcinoma (HNSCC) patients and reporting on programmed death-ligand 1 (PD-L1) expression, overall survival (OS), progression-free survival (PFS), and objective response rate (ORR). This study included three randomized clinical trials (RCTs) with a combined total of 2371 participants. The analysis incorporated studies conducted up to October 2023.
The study showed tha…