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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Escherichia coli (E. coli) & Fluorouracil (5-FU)

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Antibacterial Effects of 5-FU on Escherichia coli

5-Fluorouracil (5-FU) is known for its significant antibacterial properties, particularly against Escherichia coli (E. coli).
Zhang et al. 2024c Antibiotics (Basel) 13(6): 528
Diógenes et al. 2025 Microb Pathog 206: 107701

5-FU reduces biofilm formation in Escherichia coli (E. coli) K-12 strains by acting through the global regulator AriR, serving as an antivirulence compound.
Attila et al. 2009 Appl Microbiol Biotechnol 82(3): 525-33

Mechanism of Action

Fluorouraci…

References (Sources)

5-Fluorouracil reduces biofilm formation in Escherichia coli K-12 through global regulator AriR as an antivirulence compound
Attila et al. 2009 Appl Microbiol Biotechnol 82(3): 525-33
Deciphering the Antibacterial Mechanisms of 5-Fluorouracil in Escherichia coli through Biochemical and Transcriptomic Analyses
Zhang et al. 2024c Antibiotics (Basel) 13(6): 528
Effect of 5-fluorouracil on Escherichia coli and Enterococcus spp.: insights into the selective pressures caused by this cytotoxic drug
Diógenes et al. 2025 Microb Pathog 206: 107701
The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota
LaCourse et al. 2022 Cell Rep 41: 111625

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