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meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

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Acute liver failure (ALF) & Toxins

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During Acute liver failure (ALF), toxins are normally metabolized by phase I enzymes such as cytochrome p450 2E1 (CYP2E1) and transformed into reactive species, which cause cell oxidative damage and liver failure
Lee et al. 1996 J. Biol. Chem. 271: 12063-12067
Ge et al. 2021 Cell Death Dis. 12: 76

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Period1 mediates rhythmic metabolism of toxins by interacting with CYP2E1
Ge et al. 2021 Cell Death Dis. 12: 76
Role of CYP2E1 in the hepatotoxicity of acetaminophen
Lee et al. 1996 J. Biol. Chem. 271: 12063-12067

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Acute liver failure (ALF) & Toxins

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