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Analysis of patient fecal microbiome samples (n=43, 30R, 13NR) showed significantly higher alfa diversity (p<0.01) and relative abundance of Ruminococcaceae (p<0.01) in responding patients.
Meta-sequencing analyses of bacterial 16S ribosomal DNA amplified from stool samples of 38 patients with solid tumors (14 with lung cancer and 24 with gastric cancer), who received anti-PD-1 therapies, were done. Tumor-infiltrating lymphocytes (TILs) were analyzed from 17 patients.
There were significant differences in the divers…