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During gastrointestinal tumorigenesis, immunosuppression in the Tumor Microenvironment (TME) directly contributes to T cell depletion. Soluble factors from tumor or stromal cells collectively shape the suppressive immune environment.
Fibroblasts, neuronal cells, soluble cytokines, exosomes, and [gut microbiota](brain://b0e4tBtkY0q65p9RSVDwHQ/GastrointestinalCancersGu…