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Anti-Tumor Necrosis Factor alfa (TNF-alfa) antibodies / Tumor Necrosis Factor alfa (TNF-alfa) inhibitors are crucial for treating Inflammatory Bowel Disease (IBD). They are highly effective (1, 2, 3, 4)
However, there are some issues: Serious systemic side effects, high treatment costs, ineffectiveness in certain patient groups (2, 3, 4)
Anti-TNF therapy fails in up to 50% of patients (2, 3, 4)
Over half of the patients lose responsiveness over time (2, 3, 4)
Alternative treatments are necessary for patients resistant to anti-TNF therapy.
Four monoclonal anti‑TNF agents are established in IBD (5):