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In the context of CD4+ CD25+ FOXP3 high Treg (peripherally induced) & MTOR signal transduction pathway / mTOR (mammalian target of rapamycin), CD4+ Foxp3+ regulatory T cells (Treg) are vital. They keep immune tolerance. Losing them causes fatal autoimmune issues in mice and humans. Reports on their metabolism differ. Some say Treg have low mTOR activity. They might rely less on this kinase than conventional T cells. Others suggest the opposite. In an experimental study with mice it was found that mTOR in Treg is crucial. It helps them become effector Treg and aids their movement into [nonlymphoid tissues](brain://A91p-xpY_UW5i5hA-CFIN…