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Litifilimab inhibits the production of Interferons Type I (IFN Type I), Interferon type III (IFN Type III), cytokines, and chemokines from Plasmacytoid Dendritic Cells (pDCs) by interacting with their surface protein BDCA2. This mechanism appears responsible for initial encouraging results in treating systemic and cutaneous lupus erythematosus. Litifilimab is currently being evaluated in phase III trials with both forms.
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