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Specific microbial metabolites affect brain function.
Foster 2022 Science 376(6596): 936
Serum and cerebrospinal fluid from ALS patients show reduced levels of nicotinamide compared to healthy controls.
Foster 2022 Science 376(6596): 936
ALS is a neurodegenerative motor neuron disease that leads to muscle weakness and atrophy
Foster 2022 Science 376(6596): 936
Akkermansia muciniphila produces nicotinamide
Foster 2022 Science 376(6596): 936
The gut commensal bacterium Bacteroides ovatus can metabolize tyrosine, a common dietary amino acid, to produce p-coumaric acid, which in turn can…