Teratani et al. 2020

Recent clinical and experimental evidence has evoked the concept of the gut–brain axis to explain Mutual Interactions between the Central Nervous System and Gut Microbiota that Are Closely Associated with the Bidirectional Effects of Inflammatory Bowel Disease and Central Nervous System Disorderss1–4 . Despite recent advances in our understanding of neuroimmune interactions, it remains unclear how the gut and brain communicate to maintain gut immune homeostasis, including in the induction and maintenance of peripheral regulatory T cells (pT reg cells), and what environmental cues prompt the host to protect itself from development of inflammatory bowel diseases. Here we report a liver–brain–gut neural arc that e…