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As of December 2024, a systematic review and meta-analysis were conducted on eight trials involving 2,783 cases. This analysis focused on examining the relationship between childhood antibiotic exposure and the subsequent risk of developing pediatric inflammatory bowel disease (Pediatric Crohn's disease (CD) and Pediatric ulcerative colitis (UC) separately).
It reveals, that childhood antibiotic exposure was associated with increased Pediatric Inflammatory Bowel Disease (IBD) risk overall, with pooled RR 1.42 (95% CI 1.23-1.66). For Pediatric Crohn's di…