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Galectin-3 ligands could improve antitumor immunity in vivo.
Galectin-3 regulates autotaxin expression modulating expression of transcription factor NFAT1 / NFATC2.
Silencing galectin-3 reduced NFAT1 protein expression.
Silencing NFAT1 expression in metastatic melanoma cells inhibited tumor growth and metastatis.
Lactose inhibits galectin-3 induced cytokine production and proliferation of tumor-reactive T cells.
see also:
[Galectin-3 (Gal-3) & T cells / T lymphocytes](brain://OyVeOjY5jFuQMs3zP…