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The immunoregulatory cytokine IL-27 upregulates inhibitory immune checkpoint receptors (eg, CD274 (Programmed death-ligand 1 (PD-L1))](brain://CkaaYsNp7lKeL9t6TttrFQ/B7h1Pdl1Cd274), TIGIT) and downregulates pro-inflammatory cytokines (eg., Interferon Type II (IFN Type II) / Interferon Gamma (IFN-g), Tumor Necrosis Factor alfa (TNF-alfa). SRF388 is a fully human IgG1 blocking antibody to IL-27 with potential to promote immun…