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Interaction between antibody-bound target cells - for example, infected or tumor cells - and complement factors
Mantuano et al. 2020
Complement activation culminates in the assembly and deposition of Complement membrane attack complex (MAC) that kill infected or damaged cells through disrupting membrane integrity.
The effect of complement on cells is regulated by so-called membrane-bound complement regulatory proteins (glycoproteins). If these regulatory proteins are downregulated on renal cell carcinoma cells, complement-mediated cytotoxicity works via the interaction of the complement factors C3 and C5.…