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Cholesterol is a complex metabolite influencing cancer, atherosclerosis, and autoimmunity. It affects both adaptive and innate immunity through various metabolites. Altered cholesterol metabolism is common in many cancers, and manipulating it may enhance immunotherapy. Cholesterol's role can be both pro-inflammatory and anti-inflammatory, depending on the context and immune cell types involved. Understanding cholesterol-related metabolites can improve insights into their functions and aid in developing future therapeutic strategies against cancer and other diseases.
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