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Interferon regulatory factor 8 (IRF8) is required at multiple stages of cDC1 development, but its role in committed cDC1 remains unclear.
Lança et al. 2022 Immunity 55: 1431-1447
In the absence of Irf8, committed cDC1 acquired the transcriptional, functional, and chromatin accessibility properties of cDC2.
Lança et al. 2022 Immunity 55: 1431-1447
IRF8 expression by committed cDC1 is required to prevent their conversion into [cDC2](brain://TGt8B0RJqkqKwWWYyXdy6Q/Conventi…