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Differentiated mast cells (MCs) are crucial in IgE-mediated allergic diseases such as pollinosis and food allergies.
If the high-affinity receptor for IgE, FceRI, crosslinks through the IgE and Ag (Ag) complex, rapid degranulation, eicosanoid release, and cytokine production with allergic symptoms occur in mast cells.
Although much about the underlying mechanisms is still unknown, SCFAs appear to have an anti-allergic effect on mast cells
The current study demonstrated that oral administration of butyrate and valerate improved IgE-mediated anaphylaxis in mice. SCFAs significantly reduced IgE-induced degranulation and cytokine production of bone marrow-derived mast cells (BMMCs).
Butyrate and valerate are thought to regulate mast cells via the GPR109A receptor and through inhibition of Histone Deacetylase…