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Medical Research Finder

meRfi® Microbiome - The Digital Gut Microbiome Reference (incl. AI Chat)
Prebiotics, Probiotics, FMT / Manipulators of the Intestinal Microbiota

AuthorsReferences (Sources)

Pattern Recognition Receptors (PRRs) & Signal transduction

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Pattern Recognition Receptors (PRRs) signalling dysfunction is linked to inflammatory diseases such as Inflammatory Bowel Disease (IBD) and necrotising enterocolitis.
Neu et al. 2011 N Engl J Med 364: 255-64
Jostins et al. 2012 Nature 491: 119-124

Genetic polymorphisms in Pattern Recognition Receptors (PRRs) like NOD2 and CD284 (Toll-Like Receptor 4 (TLR-4)) increase Inflammatory Bowel Disease (IBD) risk.
Gaya …

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Jostins et al. 2012 Nature 491: 119-124
Inflammatory bowel disease
Kaser et al. 2010 Annu Rev Immunol 28: 573-621
Review
Necrotizing enterocolitis
Neu et al. 2011 N Engl J Med 364: 255-64
New genes in inflammatory bowel disease: lessons for complex diseases?
Gaya et al. 2006 Lancet 367: 1271-84
Review
Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk
Lee & Kim, 2007
Review

7/1/2026