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(1) Association with Lower Tumor Burden: Members of the Clostridiales order in the gut microbiota are associated with a lower tumor burden in mouse models of colorectal cancer (CRC).
(2) Reduction in CRC Patients: These beneficial commensal species are significantly reduced in CRC patients compared to healthy controls.
(3) Therapeutic Potential: Oral administration of a mix of four Clostridiales strains (CC4) in mice not only prevented but also successfully treated CRC as a stand-alone therapy.
The therapeutic effect of the mix of four Clostridiales strains (CC4) was dependent on the intratumoral infiltration and activation of [CD8+ T cells](brain://s-pKF05-6kiTAg3gOHq…