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High grade glioma is one of the severe form of tumour that progresses in the glial cells of the brain and spinal cord. Age, gender, exposure to infections, race, ethnicity, viruses and allergens, environmental carcinogens, diet, head injury or trauma and ionizing radiation may report with increased glioma risk. Headache, seizure mainly generalized tonic-clonic seizure, memory loss and altered sensorium are considered as common symptoms of glioma. Magnetic Resonance Imaging (MRI), CT scans, neurological examinations and biopsy are considered as the diagnostic option for glioma. Treatment for glioma mainly depended upon the tumour progression, malignancy, cell type, age, location of tumour growth and anatomic structure. The standard treatment includes surgery, radiation therapy and chemotherapy. Temozolomide is…