Secretase / Amyloid-beta precursor protein secretase

Amyloid-beta, often abbreviated as Aß or Abeta, is a byproduct of the cleavage of amyloid precursor protein (APP). APP itself is a transmembrane protein that undergoes a cleavage process through an amyloidogenic pathway, which involves two specific enzymes: beta-secretase and gamma-secretase. The enzyme beta-secretase cleaves APP at a site located outside the cell, while gamma-secretase performs its cleavage at a site within the cell membrane. When proteins misfold, specifically Aβ40 and Aβ42, they serve as seeds that hasten the aggregation of proteins into structures such as oligo…