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A prospective, randomized, double-blind, parallel-group, placebo-controlled, study was performed in mechanically ventilated feed-intolerant patients [median age 55 (19–84), 73 % male, APACHE II score 18 (5–37) with a gastric residual volume ≥200 mL]. Gastric emptying and glucose absorption were measured both pre- and posttreatment after intragastric administration of 50 mg (n = 15) camicinal and placebo (n = 8) using the13 C-octanoic acid breath test (BTt1/2 ), acetaminophen concentrations, and 3-O-methyl glucose concentrations respectively.
Primary outcome measures:
The authors' conclusion was: When absorbed, a single enteral dose of camicinal (50 mg) accelerates gastric emptying and increases glucose absorption in feed-intolerant critically ill patients.
Chapman et al. 2016 Critical Care. 20 (1): 232…