Bacillus subtilis

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Bacillus subtilis is a probiotic bacterium. It is Gram-positive and found in fermented foods (1, 2, 3, 4, 5, 6, 7, 8).

Studies show Bacillus subtilis has anti-inflammatory effects, attributed to its exopolysaccharide (EPS) (1, 2, 3, 4, 5, 6, 7, 8).

Bacillaene and sporulation protect Bacillus subtilis from predation by Myxococcus xanthus
Müller et al. 2014 Appl Environ Microbiol 80: 5603-5610
Bacillus subtilis exopolysaccharide prevents allergic eosinophilia
Swartzendruber et al. 2019 Allergy 74: 819-821
Bacillus subtilis-mediated protection from Citrobacter rodentium-associated enteric disease requires espH and functional flagella
Jones & Knight 2012 Infect Immun 80: 710-719
Exopolysaccharide from Bacillus subtilis induces anti-inflammatory M2 macrophages that prevent T cell-mediated disease
Paynich et al. 2017 J Immunol 198: 2689-2698
Modular pathway engineering of key precursor supply pathways for lacto-N-neotetraose production in Bacillus subtilis
Dong et al. 2019 Biotechnol Biofuels 12: 212
Production of Vitamin B2 (Riboflavin) by Microorganisms: An Overview
Averianova et al. 2020 Front Bioeng Biotechnol 8: 570828
Review
The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis
Butcher et al. 2007 Proc Natl Acad Sci USA 104(5): 1506-9

10/17/2026