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Activation of TGR5 by Bile Salts / Bile Acids stimulates glucagon-like peptide-1 (GLP-1) secretion from intestinal enteroendocrine L cells by increasing intracellular cAMP concentration
Changes in FXR and/or TGR5 signaling modulates the secretion of gastrointestinal hormones including glucagon-like peptide-1 (GLP-1 ) and peptide YY (PYY ), hepatic gluconeogenesis , glycogen synthesis , energy expenditure , and the composition of the gut microbiome…