NCT02734589 - Ulcerative colitis exclusion diet (UCED) vs Fecal Microbiota Transplantation (FMT) + Ulcerative colitis exclusion diet (UCED) vs Fecal Microbiota Transplantation (FMT) & Ulcerative Colitis (UC)

Background:

It is currently unclear whether the integration of novel diets for donors and patients in addition to fecal transplantation could increase the remission rate of fecal transplantation in refractory ulcerative colitis (1).

Study overview:

It is a three-arm, single-blind, randomized treatment trial testing a novel “Ulcerative colitis exclusion diet (UCED) vs Fecal Microbiota Transplantation (FMT) vs Fecal Microbiota Transplantation (FMT) + Ulcerative colitis exclusion diet (UCED) in 62 enrolled adults with mild–moderate, medication‑refractory Ulcerative Colitis (UC) (1)

Primary oucome measures:

Clinical remission

Results and conclusion:

The ulcerative colitis exclusion diet (UCED) on its own resulted in higher rates of clinical remission and mucosal healing compared to single-donor, low-frequency fecal transplantation (FMT). Additionally, incorporating donor dietary conditioning did not enhance the outcomes of FMT (1).

References:

(1) Shabat et al. 2022 Journal of Crohn's and Colitis 16(3): 369-378