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Despite promising preclinical results, only a few engineered microbial therapeutics have advanced into clinical pipelines. This gap highlights the need for microbes that offer greater precision, reliability, and context-dependent control. The innate immune system, through its pattern recognition receptors, presents accessible and tractable targets for such interventions ().
Building on foundational microbial systems understanding, systematic perturbation has become central to microbial systems biology. Techniques like …