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Perfringolysin O (PFO) is a potent toxin produced by the anaerobic bacterium Clostridium perfringens. This toxin is involved in gas gangrene and intestinal diseases.
Perfringolysin O (PFO) toxin is a pore-forming cholesterol-dependent cytolysin (CDC). Its primary function is to recognize and bind cholesterol in cell membranes. Upon binding, PFO undergoes structural changes that form large pores with a diameter of approximately 250–300 Å.
Perfringolysin O (PFO) toxin disrupts the [barrier function of the intestinal epith…