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Conventional dendritic cells 2 (cDC2) play a crucial role in orchestrating immune responses by interacting with various immune cells, including T helper 17 cells (Th17). Understanding the interplay between cDC2 and Th17 cells is essential for elucidating the mechanisms underlying autoimmune diseases, inflammation, and host defense against pathogens.
cDC2 are a subset of dendritic cells characterized by their expression of specific surface markers, including CD11c, CD11b, and MHC class II molecules. These cells are adept at capturing and presenting antigens to T cells, initiating and shaping immune responses. cDC2 are predominantly located in peripheral tissues, where they continuously sample the environment for foreign invaders or danger signals.