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Approximately 20% of patients with shingles develop Postherpetic neuralgia (PHN).
Shingles happens when the varicella-zoster virus (VZV) reactivates. This virus stays dormant in the trigeminal or dorsal root ganglia (DRGs) after chickenpox. When it reactivates, it moves to the peripheral terminals. This causes rashes and severe pain.
Globally, shingles affects 5–11 people per 1,000 person-years. About 5%–30% of …