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There are different types of MET mutations in Non-small-cell lung carcinoma (NSCLC) , and they are all summarized here under Non-Small-Cell Lung Carcinoma (NSCLC) (MET m). In detail, these are: MET Exon 14 Skipping Mutations, MET Copy Number Gain (CNG), MET Kinase Domain Mutations, MET Gene Fusions, Gain of Function (GOF) Mutations, Stage-Dependent MET Genomic Amplification
Among patients with non–small-cell lung cancer (NSCLC), MET exon 14 skipping mutations occur in 3 to 4% and MET amplifications occur in 1 to 6%.
Activation of the MET pathway through MET amplifications or mutations (MET exon 14 alterations) is present in 3–4% of stage IV non-squamous non-sm…