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In conclusion, Fecal Microbiota Transplantation (FMT) resulted in improvement of Immune checkpoint inhibitor-associated Colitis / Intestinal inflammation (ICIAC) symptoms and corresponding microbial changes in 2 cancer patients with refractory Immune Checkpoint Inhibitor-Associated Colitis (ICIAC). While more research is warranted, microbiome-modulation could be a promising new therapeutic option for Immune Checkpoint Inhibitor-Associated Colitis (ICIAC) .
ICI-associated colitis successfully treated with fecal microbiota transplantation (FMT), with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T cells (Tregs) within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis
NCT03819296
FMT could be considered as a possible treatment for ICIAC that does not respond to standard therapies, helping to prevent prolonged reliance on steroids and immunosuppressive drugs. It has been shown to effectively sustain remission of ICIAC with minimal complications. However, the influence of the gut microbiome on cancer and the potential effects of FMT are still not fully understood and require more research
see also:
Gut microbiota & Immune Checkpoint Inhibitors (ICIs)
Immune Checkpoint Inhibitor-Associated Colitis / Intestinal inflammation (ICIAC) & Drugs/Treatments
Microbiome-based therapeutics & Immune Checkpoint Inhibitor-Associated Colitis / Intestinal inflammation (ICIAC)