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A phase III, randomized, double-blind, placebo-controlled treatment trial (Parallel Assignment) evaluating dupilumab in 408 children between the ages of 6 and 11 years who had uncontrolled moderate-to-severe asthma.
Primary outcome measures:
The annualized rate of severe asthma exacerbations
Conclusion:
Children with uncontrolled moderate-to-severe asthma who received add-on dupilumab experienced fewer asthma exacerbations, improved lung function, and better asthma control compared to those who received a placebo.
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