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Surgery, local ablative therapies, and liver transplantation are the only potentially curative strategies, but most patients present with advanced disease at diagnosis or develop recurrence after surgery.
Hepatocellular carcinoma (HCC ) is a complex disease, which involves diverse molecular pathways and etiologies. In recent years, several new systemic treatments have improved survival in advanced-stage disease, but numerous significant challenges remain. No significant improvements have been achieved in the intermediate stage disease; this may be attributed to …