Corticosteroids & Ulcerative Colitis (UC)

Corticosteroids can reduce colon inflammation, but some corticosteroids (e.g., budesonide) are unsuitable for short-term treatment due to their low bioavailability and first-pass effect when taken orally
Hussenbux & Silva 2021 J. Prescribing Pract. 3: 107-111
Liu et al. 2023l Cytokine Growth Factor Rev. 71-72: 1-12

Corticosteroids for patients with moderate to severe Ulcerative Colitis (UC); systemic corticosteroids are the first-line induction therapy. It is used to alleviate symptoms in patients with moderate to severe UC and is not suitable for long-term use due to potential side effects.
Sandborn et al. 2012 Gastroenterology 143: 1218-26
Ungaro et al. 2017 Lancet 389: 1756-70
Kobayashi et al. 2020 Nat Rev Dis Primers 6: 74
Hu et al. 2021c Front. Med. 8: 766126