Fecal Microbiota Transplantation (FMT) & Immune Checkpoint Inhibitors (ICIs) Therapy (to improve)

• Fecal Microbiota Transplantation (FMT) is under study to potentially improve the efficacy of immune checkpoint inhibitors.


• Current evidence is preliminary and not sufficient to change clinical practice outside of trials.


• Near-term applications include:
  
  
  • Experimental microbiome modulation to enhance response
  
  
  • Therapeutic FMT for refractory ICI-induced colitis in selected patients.
  
  
  
  

Porcari et al. 2022 J Clin Oncol 40: suppl 6 abstr TPS407

see also:
Gut microbiota & Immune Checkpoint Inhibitors (ICIs)
[Immune Checkpoint Inhibitors (ICIs) Therapy (to improve) & Drugs/Treatments](brain://UqeO1KqZJUmxFwEit38zZw/ImmuneCheckpointInhibitorsICIsTherapyToImproveDrug…