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In hypertension, the reduced number of short-chain fatty acids (SCFAs) producing bacteria is associated with modifications in gut environment, involving reduction of the hypoxic gut profile and worsening of the microbial balance, leading to a loss of epithelial barrier integrity, development of gut inflammation and the reduction of SCFAs plasma levels.
Pluznick et al. showed that GPCR receptors are able to respond to SCFAs in the vascular or renal tissues, which could lead to changes in blood pressure levels
In the [vascular endothelium](bra…