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Preclinical studies show that pre-existing behavioral disorders such as depression lead to increased vulnerability to inflammatory stimuli and that commonly used classes of antidepressants protect against this vulnerability. Behavioral disturbances are, therefore, likely to be a risk factor for Inflammatory Bowel Disease (IBD), and a protective role of antidepressants is suggested. Preclinical and clinical observations show that gut inflammation alters brain functions: triggering mood disturbances, altering [circadian rhythms](brain://33I9mVj…